Cholera and OCV in the News

June 2017: Background paper on Whole-Cell, Killed Oral Cholera Vaccines

New background paper on oral cholera vaccines has been prepared by the SAGE Working Group, WHO Secretariat, and CDC.

Read the paper (31-March-2017)

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May 2017: Safety of a killed oral cholera vaccine in pregnant women in Malawi

New DOVE observational cohort study on the safety of Shanchol in pregant women has been published in The Lancet.

Read the publication (01-February-2017)

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April 2017: Vaccination campaign necessary to stop the spread of cholera in Haiti

A mathematical model of cholera transmission in Haiti following the 2010 earthquake suggests that current approaches to cholera control and elimination, which focus primarily on improving sanitation, are not likely to solve the problem. However, eradication of cholera is possible with use of oral cholera vaccine.

Read the article (25-April-2017)

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April 2017: Cholera returns to Southern Vietnam in an outbreak associated with consuming unsafe water through iced tea

After more than a decade of steadily declining notifications, the number of reported cholera cases has recently increased in Vietnam. A matched case-control study was conducted to investigate transmission of cholera during an outbreak in Ben Tre, southern Vietnam, and to explore the associated risk factors.

Read the publication (13-April-2017)

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March 2017: Oral cholera vaccination campaign launched in Somalia

The Government of Somalia has launched its first oral cholera vaccination (OCV) campaign with the support of WHO, targeting over 450,000 people in 7 high-risk areas around the country.

Read the article (15-March-2017)

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March 2017: El Niño and the shifting geography of cholera in Africa

In the wake of the 2015–2016 El Niño, multiple cholera epidemics occurred in East Africa, including the largest outbreak since the 1997–1998 El Niño in Tanzania, suggesting a link between El Niño and cholera in Africa.

Read the study (8-March-2017)

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February 2017: Turning the Tide Against Cholera

A global pandemic rose from these swamps. Now scientists may have a way to stop it.

Read the article (6-February-2017)

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January 2017: "Sorry doesn't heal the scars"

In the wake of the recent Haiti cholera outbreak, Claire Panosian Dunavan interviews Dr. Louise Ivers.

Read the interview (11-January-2017)

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January 2017: Adapting to the Global Shortage of Cholera Vaccine: Targeted Single Dose Cholera Vaccine in Response to an Outbreak in South Sudan

Findings from a Personal View published in The Lancet document the first public health use of a reduced, single-dose regime of oral cholera vaccine.

Read the article (18-January-2017)

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January 2017: WHO: Oral Cholera Vaccine, One of the Crucial Tools to Prevent Cholera

A new video released by the World Health Organization explains what the oral cholera vaccine and why it is so crucial to preventing cholera.

Watch the video (22-December-2016)

 

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December-2016: Cholera Rapid Test with Enrichment Step Has Diagnostic Performance Equivalent to Culture

Cholera rapid diagnostic tests (RDT) could play a central role in outbreak detection and surveillance in low-resource settings, but their modest performance has hindered their broad adoption.

Read the article (December 2016)

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December-2016: Eliminating Cholera Transmission in Haiti

On October 13 and 14, 2016, the minister of health and population in Haiti, Daphnee Benoit, convened an expert panel at the U.S. National Institutes of Health to consult on the control of cholera in Haiti with specific reference to the use of vaccines in the aftermath of hurricane Matthew. 

Read the perspective (December 2016)

 

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December-2016: Cholera Rapid Test with Enrichment Step Has Diagnostic Performance Equivalent to Culture

Cholera rapid diagnostic tests (RDT) could play a central role in outbreak detection and surveillance in low-resource settings, but their modest performance has hindered their broad adoption.

Read the article (December 2016)

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December-2016: Eliminating Cholera Transmission in Haiti

On October 13 and 14, 2016, the minister of health and population in Haiti, Daphnee Benoit, convened an expert panel at the U.S. National Institutes of Health to consult on the control of cholera in Haiti with specific reference to the use of vaccines in the aftermath of hurricane Matthew. 

Read the perspective (December 2016)

 

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September-2016: Potential for Controlling Cholera Using a Ring Vaccination Strategy: Re-analysis of Data from a Cluster-Randomized Clinical Trial

Findings from an observational study published in PLOS Medicine suggest that high-level protection can be achieved if individuals living close to cholera cases are living in a high coverage ring. 

Read the article (September 2016)

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June-2016: Newsletter of the Global Task Force on Cholera Control

The Global Task Force on Cholera Control (GTFCC) published it's third issue of Cholera Network News, affectionately known as "CNN". This issue focuses mainly (but not only) on the updates regarding the different domains of the GTFCC Working Groups and on progress towards providing evidence based recommendations for the implementation of cholera control. 

Read the newsletter (June-2016)

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29-June-2016: Cholera vaccine developed by University of Maryland wins FDA approval

Federal regulators have approved a cholera vaccine, Vaxchora, developed by the University of Maryland that will provide U.S. travelers with the first defense against the virulent infection common in many poor countries. 

Read the announcement (29-June-2016)

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18-March-2016: The oral cholera vaccine Shanchol when stored at elevated temperatures maintains the safety and immunogenicity profile in Bangladeshi participants

A new study in Vaccine, is the first of its kind to show that the oral cholera vaccine is stable at elevated temperatures, and the safety and immunogenicity profiles are not altered. The study was conducted among 580 participants aged 18-45 years in Mirpur, Dhaka, Bangladesh. Four groups received two doses of vaccine, kept under standard storage temperatures (Group 1: 2-8°C; Group 2: 25°C; Group 3: 37°C; Group 4: 42°C) for 14 days. 

Read the article (18-March-2016)

 

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2-Oct-2015: Weekly Epidemiological Record - Cholera, 2014

The Weekly Epidemiological Record (WER), 2 October 2015, vol. 90, 40 (pp. 517–544), is dedicated to cholera, including cholera control efforts, innovative WASH interventions to prevent cholera, surveillance, rapid diagnostics and laboratory networks, and stories on cholera in Bangladesh and Haiti.

The WER serves as an essential instrument for the rapid and accurate dissemination of epidemiological information on cases and outbreaks of diseases under the International Health Regulations and on other communicable diseases of public health importance, including emerging or re-emerging infections.

Read the Weekly Epidemiological Record (2-Oct-2015). 

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26-Aug-2015: Single Cholera Vaccine Dose May Slow Cholera Epidemics

Voice of America discusses the findings of a new study in PLoS Medicine, The Impact of a One-Dose versus Two-Dose Oral Cholera Vaccine Regimen in Outbreak Settings: A Modeling Study.

When it comes to a vaccine to prevent cholera, one dose may be as good as two. That is the finding of a new study whose authors say the strategy would make a new vaccine that is in short supply go further. In the study, researchers looked at the cholera epidemic in Port-au-Prince, Haiti, following the 2010 earthquake. Roughly 120,000 people contracted the bacterial disease and more than 800 died. But writing in the journal PLOS Medicine, they say if a single dose of the oral vaccine had been administered to the population within a year of the earthquake and the first reported cases, more than 78,000 cases of cholera might have been prevented and 783 deaths averted. Read the Voice of America post (26-Aug-2015) or the publication (25-Aug-2015). 

 

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3-June-2015: Lions in the Winter - Public health legends

Dr. David Sack and Dr. Brad Sack, brothers,  have been on the front lines of the cholera wars for a combined 90-plus years. Together they’ve helped save millions of lives, and have helped to turn what was once a death sentence into a fighting chance at life. Read the article (3-June-2015).

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25-Mar-2015: 160,000 people targeted with oral cholera vaccine in Nsanje

In response to flooding in Nsanje district in Malawi, the Ministry of Health is embarking on a campaign to administer oral cholera vaccine to a targeted 160,000 people at risk for cholera. Settie Kanyanda of the Ministry of Health explained that “Nsanje district is experiencing more cases of cholera as compared to other districts. We feel that the Oral vaccine is a preventive measure to the attacks." This effort is supported by the World Health Organization and the International Vaccine Institute of Korea.  Read the article (25-Mar-2015) or the press release (25-Mar-2014).

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04-Sept-2014: 200,000 people immunized against cholera in South Sudan

Doctors Without Borders/Médecins Sans Frontières (MSF) has made tremendous progress in protecting vulnerable populations from cholera in South Sudan. Read the article (04-Sept-2014) or watch the video (20-Aug-2014).

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19-Apr-2014: U.N. struggles to stem Haiti cholera epidemic

The New York Times assesses the United Nations's response to the cholera epidemic in Haiti and the consequences of lack of funding for vaccination, infrastructure building, and treatment.

Attention is focused on the shortfall in funding in light of concerns about the upcoming rainy season, during which as many as 40,000 people could become infected. Of the $5 million needed to vaccinate pople who may be vulnerable, $38 million needed for lifesaving supplies like water purification tablets, and $2 billion needed to build the water and sanitation infrastructure, only a small portion has been raised. U.N. officials have cited "donor fatigue" for this funding gap.

Read the NY Times article (19-Apr-2014)

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22-Feb-2014: South Sudan OCV campaign is first use of WHO stockpile

The WHO is coordinating with the South Sudanese government, International Federation of the Red Cross and Red Crescent Societies (IFRC), Médecins Sans Frontières (MSF) and UNICEF to bring the oral cholera vaccine (OCV) to 140,000 people.

This campaign targets people living in Minkaman camp in Awerial County and Juba camp. Although there is no cholera outbreak, overcrowding and poor sanitation puts people in the camps at significant risk for cholera. OCV is an important preventative tool to be used alongside water and sanitation efforts. This is the first use of the emergency vaccine stockpile since the stockpile's creation in 2013.

Read the WHO press release (22-Feb-2014)

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22-Nov-2013: The GAVI Alliance has added the oral cholera vaccine to its portfolio

GAVI Alliance

On 22-Nov-2013, GAVI committed funds to support increasing the stockpile of oral cholera vaccines, ensuring that millions more doses of life-saving vaccine will be delivered to those in need in outbreak situations and endemic settings.

Currently, the OCV stockpile is managed by the WHO and consists of 2 million doses. During the period of 2014-2018, GAVI will make financial contributions for OCV procurement, with the goal of gradually increasing the stockpile to approximately 20 million doses.  A recent study found that oral cholera vaccines protect for up to 5 years. Integrating vaccine into cholera programs can help #stopcholera

Frequently asked questions on cholera vaccines

Read the GAVI Press Release (22-Nov-2013)

 

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